The study concludes that the interaction of steric and electronic effects leads to the preferred formation of 2-CF 3-quinolines, which provides us with some information on how to manipulate the Combes quinoline synthesis to form a desired regioisomer as the product.
2.
The Combes quinoline synthesis is often used to prepare the 2, 4-substituted quinoline backbone and is unique in that it uses a ?-diketone substrate, which is different from other quinoline preparations, such as the Conrad-Limpach synthesis and the Doebner reaction.
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